%0 Journal
%T Racemization in reverse: evidence that D-amino acid toxicity on Earth is controlled by bacteria with racemases.
%A Zhang G,Sun HJ
%J PloS one
%V 9
%P e92101
%D 2014
%X D-amino acids are toxic for life on Earth. Yet, they form constantly due to geochemical racemization and bacterial growth (the cell walls of which contain D-amino acids), raising the fundamental question of how they ultimately are recycled. This study provides evidence that bacteria use D-amino acids as a source of nitrogen by running enzymatic racemization in reverse. Consequently, when soils are inundated with racemic amino acids, resident bacteria consume D- as well as L-enantiomers, either simultaneously or sequentially depending on the level of their racemase activity. Bacteria thus protect life on Earth by keeping environments D-amino acid free.